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Histo . FACT

Histoplasmosis Induction and Consolidation Therapy Factorial Randomized Clinical Trial

Research Approach

Innovative Research

Leverage state-of-the-art scientific approaches to develop and introduce therapies in Histoplasmosis

Translation + Dissemination

Generate evidence that informs clinical care, shapes policies, and guidelines, and drives meaningful change on a global scale.

Mentorship

Train and mentor the next generation of researcher to lead new innovations in mycology and HIV medicine.

About Histoplasmosis

What is histoplasmosis?

Histoplasmosis is an infection caused by a fungus called Histoplasma that lives in the environment, especially in soil. People can get this infection by breathing in tiny spores from the fungus.

Histoplasmosis Lifecycle
Source: Centers for Disease Control and Prevention (US). How People Get Histoplasmosis [Internet]. Atlanta (GA): CDC; [updated 2024 May 14]. Available from: https://www.cdc.gov/histoplasmosis/causes/index.html
For additional information, visit the U.S. Centers for Disease Control and Prevention .

Who gets sick?

Many people who breathe in the spores do not get sick at all. When illness does occur, symptoms can be mild, like a cough or flulike feelings. Some people, especially those with weakened immune systems, can develop a more serious infection.

How serious can it be?

Most cases affect the lungs and go away on their own. In rare cases, the infection can spread to other parts of the body and become life-threatening if not treated.

Where is it found?

Histoplasmosis occurs in many parts of the world, with higher risk in certain areas. In the United States, it is estimated that more than 500,000 cases occur each year.

World Map Estimating Histoplasmosis Distribution
Source: Ashraf N, Kubat RC, Poplin V, Adenis AA, Denning DW, Wright L, McCotter O, Schwartz IS, Jackson BR, Chiller T, Bahr NC. Re-drawing the Maps for Endemic Mycoses. Mycopathologia. 2020 Oct;185(5):843-865. doi: 10.1007/s11046-020-00431-2. Epub 2020 Feb 10. PMID: 32040709; PMCID: PMC7416457.